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Combating COVID-19 with Zinc and Quercetin

A South Korean research paper has demonstrated in Vitro that by increasing the Zinc concentration in cellular cytoplasm, that viral replication is inhibited. As intracellular levels of Zinc are increased the inhibition of viral replication can reach 100% according to charts within the paper. The researchers used two antimalarial drugs which are Ionophores. Ionophores are molecules that can carry a charged ion like Zinc across a cellular membrane. South Korea has been treating high risk, Critically I’ll COVID-19 patients with the drug Hydroxychloroquine. It is likely the single clinical reason that South Korea has the lowest death rate in the world for COVID-19 victims of 0.6% Hydroxychloroquine is a pharmaceutical drug that requires a prescription. However there is a nutritional supplement called Quercetin that is a Zinc Chelator and Ionophore and requires no prescription. It’s interesting that there has been a great deal of research done on the ability of Elderberries as and antiviral agent. And Elderberries, Red Wine and Blueberries all three have high amounts of Quercetin. It may be likely that the high Quercetin content of these foods is the reason for their measurable anti-viral properties. So what would be better than supplementing Zinc and Quercetin together to elevate intracellular Zinc levels in order to inhibit viral replication? Since there have been no Clinical Trials of this supplement regimen then dosages are your best guess. But even increasing Zinc to levels that result in a thirty percent inhibition seems like a major advantage to the patient, and may be enough to tip the struggle in your favour. NutritionalPharmacology@Gmail.com

100 replies on “Combating COVID-19 with Zinc and Quercetin”

Omg! This makes soooo much sense! I can’t believe I stumbled on this information… I found zinc ionophores for sale alone sold as “Zinc ionophores” or should I get the individual zinc and quercetine? Thanks!

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Any dose of Zinc over 7 mg in a five hour period is a waste because this is the most the body can utilize while the excess is excreted in the urine(water soluble).
Because no in vivo studies have been conducted, dosing should be done cautiously. The increase in intracellular zinc levels inhibits the translation of the virus, but will also likely suppress the formation of polypeptides like the proteins and enzymes required for healthy cell function. So it is likely that you do not want to exceed minimal daily dosing(500 mg of Quercetin and 10 mg of zinc) until you become ill. Or even try a minimal dose every two days instead of daily(to be safe). It’s best to listen to your body with this one and if you begin to feel less well from the supplements, stop taking them. Once ill(from Coronavirus) then increase the dosing with at least a 5 hour interval between doses..
The lack of in vivo studies with this combination also means that the long term effects of even low dose supplementation is not understood. And by artificially elevating intracellular zinc levels to unnatural levels, it might not be a good idea to get carried away blindly.
What may be better is to eat foods high in Quercetin and zinc. Elderberries and elderberry powder may be a good natural, balanced source of Quercetin with all the associated flavonoids that work synergistically together, which is very important. Oysters are one of my favourite natural sources of zinc. A single large oyster can have up to 25 mg of this trace mineral.
And by getting them through food, keep your bottled supplements on hand to escalate your defences if you need to combat the infection as an imminent threat, and not a potential threat.

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I suspect if your iron levels are getting low then you should have a ferritin test. Typically men because they don’t menstruate have much higher iron plasma levels and may explain the increased risk of men in acquiring Coronavirus. It may be beneficial to increase zinc intake for some, just to decrease iron accumulation which is highly toxic.

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Hi there, thanks so much for this article! I apologize if this’s a dumb question, but: i’m still wondering how to take in zinc ‘ionospheres’? I have some lozenges, and i bought some quercetin- is it a good protocol to take the quercetin prophylactically daily, and then when ‘the stuff hits the fan’, start taking the zinc lozenges? That’s what I was planning on. Or should i find that ‘zinc glycinate’ version, and take that prophylactically. And then, should one get sick, they start taking the quercetin as well?
Sorry if this’s redundant, I just can’t seem to tell. Again- thank you, thank you! Jeff

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David, thank you so much for taking the time to respond. Truly appreciate it!
If i may bug you further, for clarification: the zinc glycinate already has something similar to the quercetin in it? And so i would then need to stop the quercetin daily? UNLESS got infected, and then one would/could start quercetin to increase delivery?
If so, am just wondering how this fits in with the other narrative- of quercetin being quite beneficial. They’re doing a COVID trial on it in Canada. And there’s these studies someone linked to
https://www.ncbi.nlm.nih.gov/pubmed/22350287
https://www.sciencedirect.com/science/article/pii/S2352914816300065

Again, thank you for taking the time to help me! Jeff

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Quercetin in the ionophore which means that it helps to transport zinc to where it needs to go. Zinc itself Is antiviral and if your levels are low you may be more susceptible to a virus or the severity of the virus may be worse. It would be prudent to take the zinc supplement either as a lozenge or As zinc picolinate or zinc gluconate. You can take it with Quercetin to prevent or when “the shit hits the fan“ as you said. I think it would be smart to do the zinc prior to but you may have a hard time finding it at this point.

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Warning: Taking zinc on an empty stomach is not a good idea as it can trigger vomiting. I read somewhere that 50 mg of zinc per day helps combat flu and COVID-19. My husband does best at 25 mg. Once the flu or COVID-19 strikes, then zinc can be increased to 100 mg or even 150 mg, but only for three days. We take quercetin and zinc picolinate along with yogurt and blueberries. Currently, zinc is in very short supply.

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If you scroll up through my comments, then you will “READ” that the human body can not adsorb more than 7 mg of zinc in a five hour period. So any dosage over 7 mg is a waste of money and may not be healthy especially if you are familiar with the science behind Toxicology! Even Table Salt at high enough dosages can be FATAL!

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You need a low stomach acid PH to absorb zinc – a little apple cider vinegar can help. You also need salt, iodine, B1 and energy to make sufficient stomach acid as per Dr Jerry Tennant MD (see his 2014 IAOMT lecture on YouTube)

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Hi David, I have a question about a study you mention above: Zinc Ionophore Activity of Quercetin and Epigallocatechin-gallate: From Hepa 1-6 Cells to a Liposome Model. I believe this is also the study mentioned by Dr. Seheult in his Medcram series. In the study it was shown that Epigallocatechin-3-gallate (EGCG) was superior to Quercetin as a zinc ionophore by a wide margin. Both are available as supplements. Why do you think it is that QCT is mentioned and EGCG is not? Even Dr. Seheult only mentions the QCT and dosages of 3-7 grams daily as per the study.

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I don’t think 3-7 GRAMS of Quercetin is safe daily dose for humans … that is tremendous dose – it would be overwhelming.

You could take both Quercetin and Epigallocatechin-3-gallate in normal does…. I think that would maximize the Zinc ionophore capabilities – top it off with a Vodka Tonic. 😉

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It’s not known, there have been no in vitro or in vivo trials.
A Canadian trial was commenced by McGill University in Montreal two weeks ago regarding Quercetin alone.
Quercetin has well established benefits to lung health, which may be important when combatting a lung infection like COVID-19

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from what I have read, zinc picolinate is the most soluble, and thus should get the best results available through amazon, not very expensive

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My wife has recently developed GI symptoms now considered indicative of early COVID-19 infection in younger individuals. (study: https://journals.lww.com/ajg/Documents/COVID_Digestive_Symptoms_AJG_Preproof.pdf )

She had diahrrea and complete loss of apetite followed by nausea for 3 days in total now (diahrrea luckily only 1st day). We don’t know if it’s COVID-19 or not as GI issues are still not even considered related to COVID-19 in Canada.

I’ve been following COVID-19 very closely since the start and have seen the original medcram video right when it came out. Ordered Quercitin the same day so we have good supply.

My wife is now on 1600mg quercitine a day in 4 doses 400mg each. We don’t have direct zinc supplements but she takes a full multivitamin with minerals daily at 8mg of zinc.

I’m wondering how the absorbtion of zinc and quercitin and their function are different in the GI tract compared to the more typical areas considered?

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I wish that was possible. Right now Alberta is doing ~3k tests a day and they’re still mostly only doing severe cases and typical symptoms. If the problem persists for another day or two I’ll try calling them for a test for her, but doubt they’d allow it for someone with 0 respiratory symptoms so far.

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Relax! Don’t get your brain in a cramp. I’d get 10 mg of zinc citrate(cheap and good). I’d cut down to 400 mg if quercetin, but take the zinc and quercetin first thing in the morning on an empty stomach. Don’t consume anything but water for at least an hour. This is what you have to do because quercetin is a chelator.
If she develops more symptoms of COVID-19, then do exactly the same thing two times a day. It takes three hours after you eat to empty the stomach. Make sure there is at least five hours between these dosages.
👌

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I wouldn’t take Zinc on an empty stomach Because it makes me throw up. I always suggest it at meal time because you need acid in your stomach to help break down the zinc.

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If you take the quercetin with the zinc and food, the quercetin will combine with other minerals and everything except the zinc.
By taking them together on an empty stomach you are ensuring the quercetin and zinc combine and are adsorbed into the blood plasma. This is how a chelator has to be utilized for this application! Do you get it?

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Of course 😀

What I meant was if the different cell types (e.g. the ones in small intestine lining) have the same mode of action when it comes to taking zinc into the cytoplasm as compared to other ACE2 exposing cells like the ones in the lungs. I’m guessing “yes” but didn’t know.

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In the end we both got sick (not surprising with R0 of 6+). We’re both better now but this was psychologically the most difficult disease to go through in my life. I’ve been hospitalized just over a month ago with something completely unrelated, which was a pleasant experience compared to this.

Just in case someone is interested in our quercetin/zinc use:

We both took 400mg quercetin + ~12-13mg (half hard-pill) zinc gluconate once a day on empty stomach. It wasn’t pleasant but doable. Expect half-hour of “heavy stomach” afterwards.

As others said here I definitely wouldn’t take too much of this stuff when sick and I wouldn’t take it at all when healthy. Zinc just goes through you if you take more, I can’t figure out why they make 25mg or even 50mg pills of it. Anything over ~30-40mg of zink in one go will make you just poop it out real quick.

I’ve had my last dose today and will be switching to “multivitamin with minerals” pill 1x daily which has the typical 11mg zinc in it. I’ll only take quercetin again if I feel any kind of sickness going on.

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Be careful with the dosage of Quercetin !!! These polyaromatic phenols can cause liver toxicity !!! More is not always better !!! Do not take more than 500mg / day.
Same is true for zinc. Daily intake should probably be no more than 25mg. You can develop zinc toxicity.
Get tested if you think you have the virus and than you will be treated with the hydroxychloroquine and zinc sulfate at the higher dosages of zinc sulfate for a short time.

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The Quercetin will NOT be fully metabolized in the dihydrate form that is generally in supplements.

Only 2-10% will be absorbed and metabolized because of it’s low bioavailability. The rest will pass through the enteric canal unaltered.

It is NOT A POLY AROMATIC PHENOL.

You are confusing polyphenols with polycyclic aromatic hydrocarbons.

Quercetin is a flavonoid, specifically a flavanol, from the polyphenol group of compounds found in food and essential for human health.

Some flavonoids – like Quercetin – are broad spectrum antivirals. Quercetin has a number of beneficial processes in the body, it’s not just a zinc ionophore.

Hydroxychloroquine can cause heart arrhythmia. It’s a malaria drug.

All the people who normally take hydroxychloroquine for auto immune disorders would be better off taking Quercetin and a bioflavonoid complex in conjunction with Vitamin C (to increase bioavailability) while increasing their zinc intake through food or a low dose zinc citrate or zinc picolinate.

The same protocol should be followed if suspecting any kind of viral infection, Covid-19 or otherwise.

People’s health will continue to decline as the global populous is exposed to more environmental toxins, less nutritious food, more GMOs, unsafe medicine and unnecessary vaccines.

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there has been claims that quercetin phytosome is absorbed and utilized anywhere between 20 to 50 times more than various quercetin salts…. I have switched over to this

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Good morning all.
I am French and I live in France.
I joined your group because I am interested in using a chloroquine replacement in the fight against coronavirus. I don’t have a good command of English, but I manage. I published an article on this subject last March 27, of which here is the link for those who master French (I think in particular of David who is Swiss I think).
https://ripostelaique.com/usa-le-docteur-zelenko-guerit-100-de-ses-patients-a-la-chloroquine.html
This is a test done by Dr. Zelenko of New York; test followed by another a few days later on the basis of 700 people.
He is the only one, to my knowledge, who has used a zinc supplement on his patients (220mg of zinc gluconate per day for 5 days)
Of course, he fully understood and used the ionophore role of chloroquine zinc and his results are superior to those of Professor Raoult de Marseille who, in brackets, did not invent anything; he simply had the courage (there is no other word) to start a test based on Chinese in vitro data.
Quercetin is very interesting in particular because it does not contain the contraindications of the association chloroquine azithromycin which is known to cause multiple problems in particular cardiac because this association block the potassium channels and can cause serious arthymies and infarctions. Indeed, claritromycin, the same class of macrolide antibiotics as azithromycin, was the subject of a doctoral thesis (univ. Lille Pascale Gluais 2002) on its deleterious effects in cardiac matters, in particular the lengthening of the ” QT interval in the electrocardiogram which can lead to torsades de pointes (arrhythmias – racing heart rate – infarction). Same observation for chloroquine and even worse for mefloquine used by the Russians.
Unfortunately, the only study done on quercetin vs covid-19 is an in vitro study.
I sent an email to Doctor Michel Chrétien recently in order to know a little more about the study carried out in China on this subject. I still don’t have an answer. This is surprising since this study dates from the end of February.
One hypothesis would be that this molecule would work in vitro and not in vivo insofar as if it does indeed have an ionophore effect of zinc it also has a chelating effect of these same zinc ions. These two effects are therefore opposite since one retains the zinc ions and the other allows its penetration via the cell membrane.
In a 2006 Ebola study, the usefulness of quercetin was only demonstrated in vitro.
In addition, the ionophore functioning of quercetin would be significantly different from that of chronoquine.
Finally quercetin has an anticoagulant power which must be taken into account in particular for people who are already under such a treatment because an interaction between anticoagulant drug and quercetin is very possible with, with the key, more or less serious haemorrhages.
Thank you for your comments.
Jean Gautier
gautierjean@no-log.org

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Hydroxychloroquine is dangerous, not Quercetin.

Do you eat apples, tomatoes, peppers, red onions, broccoli, arugula, blueberries, capers, grapes?

Drink red wine?

It’s the Quercetin and polyphenol content in those foods that makes them so vital to immunity, so integral to our health.

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Partner, Quercetin from food sources is no where near the dosages possible with the supplement. This is why in vivo trials are required to determine upper safe dosages. Even table salt ingested at excessive levels is not only toxic but fatal. Because the body is a non linear system, safe dosages of any substance can only be determined in the Lab!
Hydroxychloroquine for example had very promising results in the original in vitro research, but the subsequent in vivo results yielded indications that it was worst than no treatment(placebo). A good linear theory does not have to uphold in the reality of the human body.

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This is it.A simple solution.I agree 100%.Based on the info,I think that this should work.The Icelanders consume zinc rich foods and foods with quercetin .Maybe thats why more than half of the population are asymptomatic.I bet the severity of infection is correlated with ones zinc and quercetin levels? Wanna bet?

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Robert, Jean, David,

Where can we follow the most recent information / advice on natural ionophores and zinc? Will you be keeping this thread updated? I noticed David was talking about another post elsewhere that I could not find. I think most people have questions as to dosage.

My best practice that I have gathered from everything I have read here:

Daily zinc maintenance:

~20mg a day, better taken as 10mg twice a day.

Trouble (virus symptoms):

Up the zinc to 40-200mg a day, given over several doses hours apart (what is that ideal number? Have seen variation here)

Quercetin 400-500mg a day

This would be a 5 day regimen. (Have also seen 2 weeks…)

+++

I plan on doing just under bowel tolerance levels of vitamin C as well if I do get sick.

My zinc is a lozenge that’s you dissolve in your mouth called Natures Plus High Potency Soy Amino Acid Chelate 50mg Zinc. They do not taste great, but that’s the idea!

Thank you!

Thank you.

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I’m using a tableted quercetin combined with tumeric and bromelain. Both have anti viral effects. Qct is poorly absorbed. Tablet yields sustained release. Canadian research was in vitro and animals. Both required sufficient sustained dose. Ionophore binds to zinc and carries it past cell wall bypassing zinc transporter. It fills up cells ion channels cv uses to inflame intracellularly and also inhibits serine protease reaction used by cv to mass replicate. Tablet and capsule forms together 3-4x a day to up absorption throughout day for the past week has been my regimen.

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Can you give us the link to this Canadian study that you cite? The action you describe of bypassing the zinc transport channels is the same as that of the hypothesis put forward in the Korean study. The ionophore functioning of quercetin would therefore be different from that of chloroquine.

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Partner, it’s a McGill University study commenced on March 14,2020. Google it!
The Ionophore mechanism responsible for the accumulation of intracellular zinc occurs because the cytoplasm is slightly acidic and the lysosomes are very acidic. The quercetin carrying zinc is slightly alkaline so once inside they disassociate leaving the zinc trapped inside to accumulate. It’s not rocket science.

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This post also takes a look at quercetin and points to a few papers that also suggest another possible mode of action for quercetin: Inhibition of viral entry to cells.
https://greenstarsproject.org/2020/03/27/quercetin-a-treatment-for-coronavirus/
A recent paper from a group at Oak Ridge National Lab identified quercetin as a candidate from blocking the Coronavirus spike protein from docking to human cells. That’s in theory but a couple of earlier studies found that quercetin blocked entry of three viruses: Influenza A, H5N1 and hRSV.

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I would recommend you look at the work of Dr Russell Jaffe concerning Quercitin dihydrate. He has a lot of experience using Quercitin and buffered L-ascorbate (Vitamin C). There are several different forms of Quercitin but Quercitin dihydrate has a very low side effect profile, which I can attest to by my clinical experience. I have been using it for years to treat various viral upper & lower respiratory illnesses. It will often cut the duration of illness in half. We have not done any clinical trials but the combination of Buffered L-ascorbate and Quercitin dihydrate is very effective clinically against viral pathogens. I believe it is very important to do a clinical trial concerning its use in treating Covid-19 to determine best dosages for the reasons outlined in other comments.

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One of the now recognised symptoms of COVID-19 infection is a loss of sense of taste and smell.

This is curious because from the online website What is Zinc? We find that : “Zinc is also needed for your senses of taste and smell. Because one of the enzymes crucial for proper taste and smell is dependent on this nutrient, a zinc deficiency can reduce your ability to taste or smell.”

It may be that the symptom of loss of smell and taste arises because all of the zinc inside the infected cells in the nostrils and taste buds has been used up by these cells in fighting the viral infection.

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Everyone, keep in mind that zinc and iron fight for cell receptor sites! If you take zinc on a regular basis, or too much, you will likely become endemic. And, iron is necessary to attach and transport oxygen from the lungs to the rest of the body.

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For dosages:

Click to access Marik-Covid-Protocol-Summary.pdf

I used: 500mg Quercetin,1000mg D, and 500mg C all twice a
day without discernible side effects. Taking 15mg liquid zinc drops (once a day)

I used it when I got a fever and cough.. fever went away in 24 hours.. Did I have COVID-19? No idea– but I was socially distancing and caught something.. and I haven’t had a fever in 10 years.

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Robert, appreciate you sharing the 500mg Quercetin and 10mg zinc on empty stomach for 1hour before food. 2x daily if symptoms 5+ hours apart . Do you recommend keeping your zinc levels up with a multivitamin when eating? I normally take life extension 2 a day – 12.5mg zinc in each capsule

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Zinc without the Quercetin shouldn’t excessively load zinc into your cells.
I’ve been drinking Elderberry tea instead and taking 10mg of zinc per day. There is a natural coherence in food not found in a supplant. I’m hanging on to the Quercetin until I begin to express symptoms. It’s the Big Gun I hold in reserve.

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Robert , have you seen the research paper by Goran Damchevski, maybe the key to beating Corona is in this statement?
“However, it is also shown that zinc ionophores stay in the body for at least 10 days as seen in Figure 4 from (Yao et al., 2020) so there might be a reason to suspect that with a continuous diet from quercetin sources (such as red onion, radicchio, etc), cells might be able to build up immunity against the virus”
Is this the effect you trying to get with elderberry?

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I’m concerned that the elevation of intracellularly zinc, if excessive may have long term health effects. It inhibits viral replication, but will it interfere with protein and RNA synthesis? It requires moderation until safe levels can be established.

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Little concerning, I personally have been taking quercetin 500mg twice a day on an empty stomach(all supplements recommend this method) to help stabilize my uric acid levels(gout) . I dont take it with zinc, but I would expect it would bind to any zinc in my system(I get 25mg from multi + whatever in my diet), obviously not as well as taking it directly with it.
Have been doing this for around 4 months now.

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This is the real, actual fact-based evidence:
Zinc is a mineral that’s essential for good health. It’s required for the functions of over 300 enzymes and involved in many important processes in your body. It metabolizes nutrients, maintains your immune system and grows and repairs body tissues. Your body doesn’t store zinc, so you need to eat enough every day to ensure you’re meeting your daily requirements. It’s recommended that men eat 11 mg of zinc per day, while women need 8 mg. However, if you’re pregnant, you’ll need 11 mg per day, and if you’re breastfeeding, you’ll need 12 mg. Some people are at risk of a zinc deficiency, including young children, teenagers, the elderly and women who are pregnant or breastfeeding.

However, eating a healthy balanced diet that includes zinc-rich foods will satisfy everyone’s needs.

Here are 10 of the best foods that are high zinc.

1. Meat, especially red meat., but also lamb and pork.
2. Shellfish, especially oysters. Other shellfish contain zinc, just not as much.
3. Legumes like chickpeas, lentils and beans, although, while raw, the zinc is not as well
absorbed. Heating, sprouting, soaking or fermenting legumes can increase this mineral’s
absorption in our bodies.
4. Seeds. Particularly, hemp seeds (31-43% RDI), but also squash, flax, pumpkin and
sesame seeds.
5. Nuts. Pine nuts, peanuts, cashews and almonds can boost your intake of zinc.
6. Dairy. Cheese and milk provide a host of nutrients, including zinc.
7. Eggs. Contain a moderate amount of zinc.
8. Whole grains. Wheat, quinoa, rice and oats contain some zinc.
9. Vegetables, but only certain ones. Potatoes, both regular and sweet varieties, but also
green beans and kale.
10. Dark chocolate, contains reasonable amounts of zinc, but also a lot of calories.

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Real great web site, this really responded some of my questions. Thank you!. If you have a chance check out my web site. It’s a work in progress, but I assume that someday it will have nearly as good of substance as yours.

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Good video link for your page HighPeaks,
-35:12 for preventative supplements(Astragalus, quercetin, D3)
-37:00 for preventing replication (Elderberry, zinc)
-43:30 Supplements to stop hyper immunity – lung damage (Vitamin C , melatonin, quercetin, garlic, ECGC, curcumin, mycelium mushroom)

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Longecity discussion mentions COVID can cause severe blood clotting. Doctors Best has a Natto-Sera concoction that would help IF you started to show symptoms. Would also thin lung mucus.

They just had a doctor on the news talking about it and they said that there has been so severe of blood clotting in some situations that arms or legs had to be amputated from the damage of the clot.

Reference – https://www.longecity.org/forum/topic/108038-protecting-from-coronavirus-supplements-therapies/page-39

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I’m impressed, I must say. Really rarely do I see a web page that’s both educative and fulfiling, and without a doubt, you have hit the nail on the head. Your thought is marvellous ; the issue is something that not enough people are speaking intelligently about. I am very impressed that I happened across this. If you have a chance check out my website. It’s reasonably new, but I desire that someday it will be as popular as yours kelly kosky ministries

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the link by Joseph Fine suggests the use of zinc monomethionine, for its being absorbed into the body…..there was also a comment in it that this form does not reduce the copper in the body, which is a concern with zinc…..I wonder if that fact has been verified elsewhere, because I would go with the zinc mono if true

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Dr. Chretien’s silence is disturbing considering the fanfare he received in prominent Canadian media. As is this media’s silence in lack of follow-up. Even details on his intended experiment would expand informative debate in the medical public square.

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A few days ago, I emailed the contact person for the Lazaridis Foundation which provided $1 m. for Dr. Chretien’s quercetin clinical trials. So far, no response. Kelly Crowe, science and medical writer for the CBC (Cdn Broadcasting Corporation) would seem an apt contact for pursuing this matter if one could find a direct address for her.

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